Hypercapnic acidosis attenuates pressure-dependent increase in whole-lung filtration coefficient (Kf)

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Hypercapnic acidosis attenuates pressure-dependent increase in whole-lung filtration coefficient (Kf)

Hypercapnic acidosis (HCA) has beneficial effects in experimental models of lung injury by attenuating inflammation and decreasing pulmonary edema. However, HCA increases pulmonary vascular pressure that will increase fluid filtration and worsen edema development. To reconcile these disparate effects, we tested the hypothesis that HCA inhibits endothelial mechanotransduction and protects agains...

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Hypercapnic acidosis attenuates endotoxin-induced acute lung injury.

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Buffering hypercapnic acidosis worsens acute lung injury.

Hypoventilation, associated with hypercapnic acidosis (HCA), may improve outcome in acute lung injury (ALI). We have recently reported that HCA per se protects against ALI. The current study explored whether the mechanisms of protection with HCA were related to acidosis versus hypercapnia. Because CO(2) equilibrates rapidly across cell membranes, we hypothesized that (1) HCA would afford greate...

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Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappaB dependent mechanism.

BACKGROUND Hypercapnic acidosis exerts protective effects in acute lung injury but may also slow cellular repair. These effects may be mediated via inhibition of nuclear factor-kappaB (NF-kappaB), a pivotal transcriptional regulator in inflammation and repair. OBJECTIVES To determine the effects of hypercapnic acidosis in pulmonary epithelial wound repair, to elucidate the role of NF-kappaB a...

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Hypercapnic acidosis reduces oxidative reactions in endotoxin-induced lung injury.

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ژورنال

عنوان ژورنال: Pulmonary Circulation

سال: 2017

ISSN: 2045-8940,2045-8940

DOI: 10.1177/2045893217724414