Hypercapnic acidosis attenuates pressure-dependent increase in whole-lung filtration coefficient (Kf)
نویسندگان
چکیده
منابع مشابه
Hypercapnic acidosis attenuates pressure-dependent increase in whole-lung filtration coefficient (Kf)
Hypercapnic acidosis (HCA) has beneficial effects in experimental models of lung injury by attenuating inflammation and decreasing pulmonary edema. However, HCA increases pulmonary vascular pressure that will increase fluid filtration and worsen edema development. To reconcile these disparate effects, we tested the hypothesis that HCA inhibits endothelial mechanotransduction and protects agains...
متن کاملHypercapnic acidosis attenuates endotoxin-induced acute lung injury.
Deliberate induction of prophylactic hypercapnic acidosis protects against lung injury after in vivo ischemia-reperfusion and ventilation-induced lung injury. However, the efficacy of hypercapnic acidosis in sepsis, the commonest cause of clinical acute respiratory distress syndrome, is not known. We investigated whether hypercapnic acidosis--induced by adding CO2 to inspired gas--would be prot...
متن کاملBuffering hypercapnic acidosis worsens acute lung injury.
Hypoventilation, associated with hypercapnic acidosis (HCA), may improve outcome in acute lung injury (ALI). We have recently reported that HCA per se protects against ALI. The current study explored whether the mechanisms of protection with HCA were related to acidosis versus hypercapnia. Because CO(2) equilibrates rapidly across cell membranes, we hypothesized that (1) HCA would afford greate...
متن کاملHypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappaB dependent mechanism.
BACKGROUND Hypercapnic acidosis exerts protective effects in acute lung injury but may also slow cellular repair. These effects may be mediated via inhibition of nuclear factor-kappaB (NF-kappaB), a pivotal transcriptional regulator in inflammation and repair. OBJECTIVES To determine the effects of hypercapnic acidosis in pulmonary epithelial wound repair, to elucidate the role of NF-kappaB a...
متن کاملHypercapnic acidosis reduces oxidative reactions in endotoxin-induced lung injury.
BACKGROUND Hypercapnic acidosis frequently occurs when patients with acute lung injury are initially ventilated with low tidal volume "protective" strategies. Hypercapnic acidosis per se, in the absence of any change in tidal volume or airway pressure, is protective when instituted before the onset of injury. However, the mechanisms by which hypercapnic acidosis confers this protection are inco...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pulmonary Circulation
سال: 2017
ISSN: 2045-8940,2045-8940
DOI: 10.1177/2045893217724414